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✅ XtalPi Announced Strategic Collaboration 👭 with Harvard Professor Gregory Verdine's DoveTree LLC
On June 23, 2025, XtalPi announced it has signed ✒️ a Letter of Intent (LOI) with DoveTree LLC, founded by Harvard University Professor and renowned biopharma entrepreneur-investor Gregory Verdine. Under the collaboration, XtalPi will leverage its end-to-end, AI and robotics-driven platform to discover and develop small molecule and antibody drug candidates for multiple DoveTree-selected targets addressing oncology, autoimmune disorders, and neurological diseases (XtalPi Announces Strategic Collaboration with Harvard Professor Gregory Verdine's DoveTree LLC to Advance Novel Therapeutics Using AI+Robotics Drug Discovery).
➡️ Professor Gregory Verdine, the Erving Professor of Chemistry at Harvard University, is a pioneer in chemical biology and a distinguished serial entrepreneur. Appointed to Harvard’s faculty at age 29, he became the Chemistry Department’s youngest tenured professor in nearly five decades at 35. He has elucidated the molecular mechanism of epigenetic DNA methylation and revealed the pathways by which certain genotoxic forms of DNA damage are identified and eradicated. He has developed a new class of therapeutics termed stapled peptides, enabling drug development against targets long considered undruggable.
➡️ Professor Verdine currently serves as a Venture Partner at Andreessen Horowitz (a16z), a role he previously held at Apple Tree Partners, Third Rock Ventures, and WuXi Healthcare Ventures. He was also a Special Advisor to Texas Pacific Group. His advisory engagements include top research institutions such as the U.S. National Cancer Institute and Harvard Medical School.
✅ Meta’s FAIR team released OMol25
Meta’s FAIR team and collaborators released Open Molecules 2025 (OMol25) (The Open Molecules 2025 (OMol25) Dataset, Evaluations, and Models), a large-scale dataset composed of more than 1️⃣0️⃣0️⃣ million density functional theory (DFT) calculations at the ωB97M-V/def2-TZVPD level of theory, representing billions of CPU core-hours of compute.
✴️ OMol25 uniquely blends elemental, chemical, and structural diversity including: 8️⃣3️⃣ elements, a wide-range of intra- and intermolecular interactions, explicit solvation, variable charge/spin, conformers, and reactive structures.
✴️ These ~8️⃣3️⃣M unique molecular systems in OMol25, cover small molecules, biomolecules, metal complexes, and electrolytes, including also structures obtained from existing datasets.
✴️ OMol25 also greatly expands on the size of systems typically included in DFT datasets, with systems of up to 350 atoms.