AI Drug Development Startups (part2)

Overview of my articles dedicated AI Design, Recruitment and Optimisation of Clinical Trials and Digital health (digital therapeutics, wearables and telemedicine) startups

AI Drug Development 🤖🚀💻💊🔬💉📑📊📈

Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery (in vitro). After drug discovery the drug candidate enters the preclinical phase where research is done on microorganisms and animals (in vitro and in vivo studies). If the preclinical phase is successful, filing for regulatory status follows — such as via the United States Food and Drug Administration — for an investigational new drug to initiate clinical trials on humans and may include the step of obtaining regulatory approval with a new drug application to market the drug. 

For every 10000 compounds screened in drug discovery, approximately 250 compounds will pass through to more rigorous preclinical studies. Eventually, 5 compounds of these 250 will pass to highly regulated clinical trials (Phase1–3). Excluding cancer drugs from the results — which made up fully 31% of all drug programs studied and have overall success rates 5.1% —the overall success rate of all other drugs that enter Phase 1 clinical trials and ultimately reaching FDA approval is 11,9%. The entire process of drug development takes 10 to 15 years and $2.6 billion to bring a drug to market.

Nowadays once a target has been identified and characterised during discovery, what usually follows is bioinformatic predictions, combinatorial chemistry, high-throughput screening, virtual screening and a lot of in silico studies (and in vitro studies). Of course data driven startups are dominating right now the entire process of drug development from drug discovery to preclinical and clinical phase. 

The first part of this blog “AI Drug Development (part 1)” (link) was an overview of my articles dedicated to AI startups and investors in the

• Drug discovery phase

  • Artificial intelligence in drug discovery (part 1): AI tools and startups for primary and secondary screening https://marinatalamanou.substack.com/p/artificial-intelligence-in-drug-discovery

  • Artificial intelligence in drug discovery (part 2): AI tools and startups for planning and execution of chemical synthesis  https://marinatalamanou.substack.com/p/artificial-intelligence-in-drug-discovery-254

  • Artificial intelligence in drug discovery (part 3): AI tools and startups for drug design  https://marinatalamanou.substack.com/p/artificial-intelligence-in-drug-discovery-e7b

  • Key AI players in the drug discovery market: AI Pharma Startups and their coronavirus initiatives https://marinatalamanou.substack.com/p/key-ai-players-in-the-drug-discovery

  • AI Drug Discovery: Top Investors https://marinatalamanou.substack.com/p/ai-drug-discovery-top-investors

• Preclinical phase

  • AI Startups in the Preclinical Phase: AI startups for designing and running preclinical experiments https://marinatalamanou.substack.com/p/ai-startups-in-the-preclinical-phase

  • AI Preclinical Phase: Top Investors https://marinatalamanou.substack.com/p/ai-preclinical-phase-top-investors

• Data aggregation process of the entire drug development process

  • AI Startups for Data Aggregation and Analysis (part1) https://marinatalamanou.substack.com/p/ai-startups-for-data-aggregation

  • AI Startups for Data Aggregation and Analysis (part 2) https://marinatalamanou.substack.com/p/ai-startups-for-data-aggregation-18b

• AI Drug Development

  • When the Pharma Giants Met the Tech Giants https://marinatalamanou.substack.com/p/when-the-pharma-giants-met-the-tech

  • Cancer and AI in a Single Frame  https://marinatalamanou.substack.com/p/cancer-and-ai-in-a-single-frame

  • AI and Pharma: a modern duel  https://marinatalamanou.substack.com/p/ai-and-pharma-a-modern-duel

The second part of the blog “AI Drug Development” is an overview of my articles dedicated to

• AI Design, Recruitment and Optimisation of clinical trials startups, and

• Digital health (digital therapeutics, wearables and telemedicine) startups trying to digitise clinical trials.

AI Clinical Trials 💊🤖

• AI Startups for Clinical Trials (part 1)_AI Design, Recruitment and Optimisation of clinical trial https://marinatalamanou.substack.com/p/ai-startups-for-clinical-trials-part

• AI Startups for Clinical Trials (part 2)_AI Design, Recruitment and Optimisation of clinical trials https://marinatalamanou.substack.com/p/ai-startups-for-clinical-trials-part-959

• AI Startups for Clinical Trials (part 3a)_Digital health: Digital therapeutics (DTx) https://marinatalamanou.substack.com/p/ai-startups-for-clinical-trials-part-5f3

• AI Startups for Clinical Trials (part 3b)_Digital health: Digital therapeutics (DTx) https://marinatalamanou.substack.com/p/ai-startups-for-clinical-trials-part-c99

• AI Startups for Clinical Trials (part 4)_Wearable startups in the mental health and wellness space https://marinatalamanou.substack.com/p/ai-startups-for-clinical-trials-part-796

• AI Startups for Clinical Trials (part 5)_Telemedicine startups in the mental health and wellness space https://marinatalamanou.substack.com/p/ai-startups-for-clinical-trials-part-08b

• Sleep monitoring digital technologies and clinical trials https://vocal.media/longevity/sleep-monitoring-digital-technologies-and-clinical-trials

Thank you for reading 💙

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